2-KetoCrizotinib(PF-06260182)是有活性的克唑替尼的内酰胺代谢产物。
货号:ajcx12988
CAS:1415558-82-5
分子式:C21H20Cl2FN5O2
分子量：464.32
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.

2-Keto Crizotinib (PF-06260182) is active and considerably less potent than crizotinib, and it is not thought to contribute significantly to the in vivo activity of crizotinib.

[1]. Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181-187.