Sauristolactam是从Saururuschinensis的气相部分分离得到的天然马兜铃内酰胺，对原代培养大鼠皮层细胞谷氨酸诱导的毒性具有显著的神经保护作用。Sauristolactam还能抑制RANKL诱导的破骨细胞生成，并有抑制破骨细胞分化的潜力。
货号:ajcx12524
CAS:128533-02-8
分子式:C17H13NO3
分子量：279.29
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells[1]. Sauristolactam also inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and has the potential to inhibit osteoclast differentiation[2].

[1]. Kim SR, et al. Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production. Planta Med. 2004 May;70(5):391-6. [2]. Li Z, et al. Saurolactam Inhibits Proliferation, Migration, and Invasion of Human Osteosarcoma Cells. Cell Biochem Biophys. 2015 Jul;72(3):719-26.