包装: | 100mg |
规格: | 98% |
市场价: | 623元 |
分子量: | 286.34 |
Background:
m-PEG4-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG4-Ms is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. Sanxing Sun, et al. Triazolotriazine derivatives as a2a receptor antagonists. WO2020002969A1.
Protocol:
Cleavable
| PEGs
|