L-Hyoscyamine-d3 (Daturine-d3) 是 L-Hyoscyamine 的氘代物。L-Hyscyamine (Daturine) 是一种天然的植物托烷生物碱，是有效的，竞争性的毒蕈碱受体 (MR) 拮抗剂。L-Hyscyamine 是 Atropine 的左旋异构体。
货号:ajcx39708
CAS:N/A
分子式:C17H20D3NO3
分子量：292.39
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

L-Hyoscyamine-d3 (Daturine-d3) is the deuterium labeled L-Hyoscyamine. L-Hyoscyamine (Daturine), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine is a levo-isomer to Atropine [1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Lars GÖran Axelsson, et al. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8. [3]. Harald John, et al. Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug Test Anal. Mar-Apr 2012;4(3-4):194-8.