包装: | 10mg |
规格: | 98% |
市场价: | 311元 |
分子量: | 409.5 |
Background:
Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].
[1]. Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.
Protocol:
5-HT1AReceptor 7.63(pKi) | 5-HT2AReceptor 10.22(pKi) | 5-HT2BReceptor 10.44(pKi) | 5-HT2CReceptor 8.42(pKi) | D2receptor 8.19(pKi) | DD4.4receptor 7.54(pKi) | M1receptor 8.61(pKi) | M2receptor 9.38(pKi) |