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Pimethixene maleate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pimethixene maleate图片
包装:10mg
规格:98%
市场价:311元
分子量:409.5

产品介绍
Pimethixene maleate 是抗组胺和抗血清素剂,用作抗偏头疼剂。Pimethixene maleate 为高效的多靶点拮抗剂,对 5-HT1A,5-HT2A,5-HT2B,5-HT2C,组胺 H1,多巴胺 D2 和 D4.4 以及毒蕈碱 M1 和 M2 的 pKi 值分别为 7.63,10.22,10.44,8.42,10.14,8.19,7.54,8.61 和 9.38。
货号:ajcx39302
CAS:13187-06-9
分子式:C23H23NO4S
分子量:409.5
溶解度:DMSO : 100 mg/mL (244.20 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent.Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].

[1]. Schmitz B, et al. BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol. 2015 Mar 15;751:73-80.

Protocol:

5-HT1AReceptor

7.63(pKi)

5-HT2AReceptor

10.22(pKi)

5-HT2BReceptor

10.44(pKi)

5-HT2CReceptor

8.42(pKi)

D2receptor

8.19(pKi)

DD4.4receptor

7.54(pKi)

M1receptor

8.61(pKi)

M2receptor

9.38(pKi)