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NCT-504
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NCT-504图片
规格:98%
分子量:404.49
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
NCT-504 是选择性的脂质激酶 PIP4Kγ 变构抑制剂,其 IC50 值为 15.8 μM。NCT-504 具有用于亨廷顿氏症疾病研究的潜力。
货号:ajcx39120
CAS:1222765-97-0
分子式:C15H12N6O2S3
分子量:404.49
溶解度:DMSO : 125 mg/mL (309.03 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

NCT-504 is a selective allosteric inhibitor of PIP4Kγ, with an IC50 of 15.8 μM. NCT-504 is potential for the research of Huntington's disease[1].

NCT-504 dose not impair the intrinsic ATP-hydrolytic activity of PIP4Kγ in the absence of PI5P substrate[1].NCT-504 does not inhibit PIP4Kbeta and weakly inhibits PIP4Kalpha phosphorylation of PI5P [1].NCT-504 dose not inhibit PIP4Kbeta or PIP4Kalpha (IC50 between 50 μM and 100 μM) at 50 μM concentration[1].NCT-504 elevates the levels of PI(3,5)P2, PI3P and PI5P in MEFs[1].NCT-504 (10 μM; 12 hours) does not affect cell viability in MEFs[1].NCT-504 (5 μM, 10 μM; 2 hours, 6 hours) elevates both the induction of autophagy as well as the rate of turnover of autophagic cargo[1].NCT-504 treatment causes a robust increase in the formation of autolysosomes with only a modest elevation in autophagosomes[1].NCT-504 increases autophagy flux and decreases huntingtin protein in 293A cells[1].NCT-504 reduces mHtt protein levels in immortalized striatal cells from knock-in HD mice[1].

[1]. Ismael Al-Ramahi, et al. Inhibition of PIP4Kγ Ameliorates the Pathological Effects of Mutant Huntingtin Protein. Elife. 2017 Dec 26;6:e29123.