MC-VA-PABC-MMAE 是抗体偶联药物 ADC 的一部分。MC-VA-PABC-MMAE 由 ADC linker (peptide MC-VA-PABC) 和强效微管蛋白聚合抑制剂 MMAE 偶联而成。
货号:ajcx38932
CAS:1818864-51-5
分子式:C65H99N9O14
分子量：1230.53
溶解度:DMSO : 100 mg/mL (81.27 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MC-VA-PABC-MMAE is a drug-linker conjugate for ADC. MC-VA-PABC-MMAE contains the ADCs linker (peptide MC-VA-PABC) and a potent tubulin polymerization inhibitor MMAE [1][2].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

[1]. Wang Y, et al. Development of applicable thiol-linked antibody-drug conjugates with improved stability and therapeutic index. Drug Deliv. 2022 Dec;29(1):754-766. [2]. Cazzamalli S, et al. Linker stability influences the anti-tumor activity of acetazolamide-drug conjugates for the therapy of renal cell carcinoma. J Control Release. 2017 Jan 28;246:39-45.