CD38 inhibitor 1 (compound 78c) 是一种有效的 CD38 抑制剂，在人类和小鼠中的 CD38 的IC50 分别为 7.3 nM 和 1.9 nM。
货号:ajcx38614
CAS:1700637-55-3
分子式:C22H27N3O3S
分子量：413.53
溶解度:DMSO : 25 mg/mL (60.46 mM; ultrasonic and warming and heat to 60°C)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CD38 inhibitor 1 (compound 78c) is a potent CD38 inhibitor with IC50s of 7.3 nM and 1.9 nM for hCD38 and mouse CD38[1].

CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle[1].

[1]. Haffner CD, et al. Discovery, Synthesis, and Biological Evaluation of Thiazoloquin(az)olin(on)es as Potent CD38 Inhibitors. J Med Chem. 2015 Apr 23;58(8):3548-71.