SHMT-IN-1 (compound (±)-46) 是有效的血浆丝氨酸羟甲基转移酶 (SHMT) 抑制剂。SHMT-IN-1 具有抗肿瘤活性。
货号:ajcx38498
CAS:1508286-18-7
分子式:C18H16Cl2N4O
分子量：375.25
溶解度:DMSO : 250 mg/mL (666.22 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SHMT-IN-1 (compound (±)-46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT). SHMT-IN-1 has antitumor activity[1].

[1]. Witschel MC, et al. Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT): cocrystal structures of pyrazolopyrans with potent blood- and liver-stage activities. J Med Chem. 2015 Apr 9;58(7):3117-30.