Fmoc-NH-PEG8-CH2COOH 是一种可降解的 ADC linker，用于抗体药物偶联物 (ADC) 合成。Fmoc-NH-PEG8-CH2COOH 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。
货号:ajcx38348
CAS:868594-52-9
分子式:C33H47NO12
分子量：649.73
溶解度:DMSO : 100 mg/mL (153.91 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Fmoc-NH-PEG8-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG8-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[1]. Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.