SK33，肌醇类似物，是一种有效的组织选择性抗雄激素药物。SK33 降低雄激素受体 (AR) 的转录活性。
货号:ajcx37930
CAS:1928724-23-5
分子式:C20H13F9N2O3
分子量：500.31
溶解度:DMSO : 100 mg/mL (199.88 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SK33, a trifluoromethylated enobosarm analog, is a potent, and tissue selective anti-androgen. SK33reduces androgen receptor (AR) transcriptional activity[1].

In LNCaPAR+ cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells. Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50 of approximately 5 μM for SK33[1].

SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity[1].

[1]. Dart DA, et al. Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer Ther. 2018 Sep;17(9):1846-1858.