Pirepemat (IRL752) fumarate 是一种儿茶酚胺和认知促进剂。Pireemat fumarate 可用于帕金森病的研究。
货号:ajcx37906
CAS:2251806-70-7
分子式:C15H17F2NO5
分子量：329.3
溶解度:DMSO : 100 mg/mL (303.67 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Pirepemat (IRL752) fumarate is a corticalpreferring catecholamine- and cognition-promoting agent. Pirepemat fumarate is used for the study of Parkinson's disease[1][2].

IRL752 fumarate displays its highest in vitro affinities for 5-HT and NA-related targets[2].

IRL752 (3.7-100 µmol/kg, s.c.) fumarate has no significant effect on acute hyper-dopaminergic or hypo-glutamatergic motor responses, but reverses deficits resulting from hypomonoaminergic function[2].

[1]. Ipsen and IRLAB Enter Exclusive Worldwide Licensing Agreement Aimed to Improve the Lives of People Living with Parkinson's Disease.
[2]. S Hjorth, et al. (3 S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752) -a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent. J Pharmacol Exp Ther. 2020 Sep;374(3):404-419.