β-Glucuronidase-IN-1 是强效的，选择性，非竞争性和具有口服活性的 E. coli β-葡萄糖醛酸酶 (β-glucuronidase) 抑制剂，针对 E. coli β-葡萄糖醛酸酶的 IC50 和 Ki 值分别为 283 nM 和 164 nM。
货号:ajcx37598
CAS:484006-66-8
分子式:C23H27N3O3S
分子量：425.54
溶解度:DMSO : 100 mg/mL (235.00 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC50 and a Ki of 283 nM and 164 nM, respectively[1].

β-Glucuronidase-IN-1 (Inhibitor 1) (0.01-100 μM) inhibits E. coli β-glucuronidase activity as a dose-dependent manner and exhibits an IC50 and a Ki value with 283 nM and 164 nM, respectively[1].
β-Glucuronidase-IN-1 (100 μM; 24-72 hours) maintains potent efficacy in living bacterial cells (EC50=17.7 nM), it does not affect bacterial cell growth under aerobic or anaerobic conditions or killing mammalian epithelial cells[1].

β-Glucuronidase-IN-1 (oral gavage; 10 μg; twice per day; 11 days) protects the mouse GI epithelium from CPT-11-induced damage and protects the glandular structure of CPT-11-treated intestinal tissues[1].

[1]. Wallace BD, et al. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.Science. 2010 Nov 5;330(6005):831-5.