MRT-14 是 Smo 的有效拮抗剂。Smo 是参与 Hedgehog (Hh) 形态发生素信号转导的主要成分。MRT-14 具有研究与异常 Hh 信号传导相关的多种癌症的潜力。
货号:ajcx37576
CAS:1263131-83-4
分子式:C24H24N4O5
分子量：448.47
溶解度:DMSO : 100 mg/mL (222.98 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

MRT-14 is a potent antagonist of Smo. Smo is the major component involved in signal transduction of the Hedgehog (Hh) morphogens. MRT-14 has the potential for the research of several types of cancers linked to abnormal Hh signaling[1].

[1]. Manetti F, et al. Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists. Mol Pharmacol. 2010;78(4):658-665.