Dimethyl Fumarate (DMF, trade names Tecfidera; Skilarence), the methyl ester of fumaric acid, is a potent, orally bioactive and brain-penetrant immunomodulator and Nrf2 activator. It has been approved by the U.S. FDA for the treatment of relapsing multiple sclerosis and by the European Medicines Agency (EMA) for managing moderate-to-severe plaque psoriasis.