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L-Leucine-15N
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Leucine-15N图片
规格:98%
分子量:132.17
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议

产品介绍
L-Leucine-15N 是一种 15N 标记的 L-Leucine。L-Leucine 是一种必需的支链氨基酸 (BCAA),可激活 mTOR 信号通路。
货号:ajcx36446
CAS:59935-31-8
分子式:C6H1315NO2
分子量:132.17
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

L-Leucine-15N is the 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.
[3]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.
[4]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.