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BIO-013077-01
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIO-013077-01图片
规格:98%
分子量:287.32
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
BIO-013077-01 是一种吡唑类的 TGF-β 抑制剂。
货号:ajcx34570
CAS:746667-48-1
分子式:C17H13N5
分子量:287.32
溶解度:DMSO : 100 mg/mL (348.04 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

BIO-013077-01 is a pyrazole TGF-β inhibitor[1].

A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies[1].

[1]. Jin CH, et al. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Eur J Med Chem. 2011 Sep;46(9):3917-25.