5-Benzyloxygramine 是 N 蛋白、蛋白互作的原位稳定剂，具有抗病毒和稳定 N-NTD 蛋白的功能。
货号:ajcx34452
CAS:1453-97-0
分子式:C18H20N2O
分子量：280.36
溶解度:DMSO : 250 mg/mL (891.71 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

5-Benzyloxygramine is a N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities[1].

5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell[1].

[1]. Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141.