PF-07321332 是一种有效的口服活性 SARS-CoV 3CLPRO 抑制剂。PF-07321332 对 SARS-CoV-2 病毒有针对性，可用于 COVID-19 研究。
货号:ajcx34106
CAS:2628280-40-8
分子式:C23H32F3N5O4
分子量：499.53
溶解度:DMSO : 140 mg/mL (280.26 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PF-07321332 is a potent and orally active SARS-CoV 3C-like protease (3CLPRO) inhibitor . PF-07321332 targets to the SARS-CoV-2 virus and can be used for COVID-19 reseacrch[1].

3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2.1. Without the activity of the SARS-CoV-2 3CLPRO, nonstructural proteins (including proteases) cannot be released to perform their functions, inhibiting viral replication[1].

[1]. KoenVandyck, et al. Considerations for the Discovery and Development of 3-Chymotrypsin-Like Cysteine Protease Inhibitors Targeting SARS-CoV-2 Infection. Current Opinion in Virology Available online 27 April 2021