您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > ROR&gammat Inverse agonist 6
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
ROR&gammat Inverse agonist 6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ROR&gammat Inverse agonist 6图片
规格:98%
分子量:565.02
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
RORγt Inverse agonist 6 (compound 43) 是 RORγt 的反向激动剂,可用于 Th17 驱动的自身免疫性疾病的研究。RORγt Inverse agonist 6 (compound 43) 通过刺激IL-23 来抑制IL-17A的表达。
货号:ajcx34090
CAS:1887161-80-9
分子式:C28H29ClN6O5
分子量:565.02
溶解度:DMSO : 50 mg/mL (88.49 mM; Need ultrasonic)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the study of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo[1].

RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model[1].RORγt Inverse agonist 6 (compound 43) exhibits improved drug exposure (mouse AUC: 1289 ng?h/mL at 1 mg/kg, po)[1].RORγt Inverse agonist 6 (compound 43, 30 mg/kg, po, b.i.d) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose[1].

[1]. Sato A, et al. Design and Synthesis of Conformationally Constrained RORγt Inverse Agonists. ChemMedChem. 2019 Oct 28.