653-47 是一种增强剂，能显著增强 666-15 的 cAMP 反应元件结合蛋白 (CREB) 抑制活性。653-47 也是一种很弱的抑制剂，其 IC50 为 26.3 μM。
货号:ajcx33408
CAS:1224678-75-4
分子式:C20H19ClN2O3
分子量：370.83
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

653-47, a potentiator, significantly potentiates the cAMP-response element binding protein (CREB) inhibitory activity of 666-15. 653-47 is also a very weak CREB inhibitor with IC50 of 26.3 μM[1].

653-47 (5-10 μM) synergistically inhibits CREB-mediated gene transcription with 666-15[1].

[1]. Xie F, et al. Discovery of a Synergistic Inhibitor of cAMP-Response Element Binding Protein (CREB)-Mediated Gene Transcription with 666-15. J Med Chem. 2019;62(24):11423-11429.