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L-AP4 monohydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-AP4 monohydrate图片
规格:98%
分子量:201.11
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
L-AP4(L-APB)monohydrate是一种有效的、代谢型谷氨酸受体(mGluR)的特异性激动剂,其对mGlu4,mGlu8,mGlu6和mGlu7受体的EC50值分别为0.13,0.29,1.0,249μM。
货号:ajcx31962
CAS:2247534-79-6
分子式:C4H12NO6P
分子量:201.11
溶解度:N/A
纯度:98%
存储:Store at -20°C
库存:现货

Background:

L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2].


L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunction[2].Intrathecal injection of 30 μg of L-AP4 does not significantly alter the paw withdrawal latency in these normal rats[2].Topical application of 5 to 50 μM L-AP4 to the spinal cord significantly inhibited the evoked response of neurons to touch, pressure, pinch, and von Frey filaments in a concentration-dependent fashion[2]. Animal Model: Rats.[2]

[1]. Selvam C, et al. Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites. J Med Chem. 2018 Mar 8;61(5):1969-1989. [2]. Chen SR, et al. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan;312(1):120-6.