SDZ285428是一种CYP51抑制剂。SDZ285428抑制Trypanosomacruzi(TC)CYP51，I/E2<1(5min)及I/E2=9(1h)。SDZ285428抑制Trypanosomabrucei(TB)CYP51，I/E2<1(5min)及I/E2=35(1h)。
货号:ajcx31828
CAS:174262-13-6
分子式:C24H20ClN3O
分子量：401.89
溶解度:DMSO: 50 mg/mL (124.41 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2<1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2<1 (5 min) and I/E2=35 (1 h)[1].

Specific inhibition of protozoan CYP51 can potentially provide treatment for human trypanosomiases[1].

[1]. Lepesheva GI, et al. CYP51: A major drug target in the cytochrome P450 superfamily. Lipids. 2008 Dec;43(12):1117-25.