VU0238441是泛毒蕈碱型乙酰胆碱受体(mAChR)阳性变构调节剂(PAM)，对M1，M2，M3，M5和M4的EC50分别为3.2μM，2.8μM，2.2μM，2.1μM和>10μM。
货号:ajcx31660
CAS:85511-68-8
分子式:C16H9ClF3NO2
分子量：339.7
溶解度:DMSO: 125 mg/mL (367.97 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively[1][2].

VU0238441 is an analogue of VU0119498[2].

[1]. Thomas M Bridges, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15;20(2):558-62. [2]. Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11;52(11):3445-8.