tcY-NH2TFA是选择性的大鼠的PAR4肽类拮抗剂。tcY-NH2TFA抑制凝血酶和AY-NH2诱导的大鼠血小板聚集。
货号:ajcx31544
CAS:N/A
分子式:C42H50F3N7O9
分子量：853.88
溶解度:DMSO: 250 mg/mL (292.78 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

tcY-NH2 TFA is a selective rat PAR4 antagonist peptide. tcY-NH2 TFA inhibits thrombin- and AY-NH2-induced rat platelet aggregation[1][2].

[1]. Morley D Hollenberg, et al. Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo. Br J Pharmacol. 2004 Oct;143(4):443-54. [2]. L Ma, et al. Thrombin-induced platelet endostatin release is blocked by a proteinase activated receptor-4 (PAR4) antagonist. Br J Pharmacol. 2001 Oct;134(4):701-4.