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MCP110
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MCP110图片
规格:98%
分子量:508.65
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
MCP110是一种Ras/Raf-1相互作用的抑制剂。MCP110阻止Ras与Raf相互作用。MCP110可用于人类肿瘤的研究。
货号:ajcx31002
CAS:521310-51-0
分子式:C33H36N2O3
分子量:508.65
溶解度:DMSO: 250 mg/mL (491.50 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

MCP110 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors[1].

MCP110 (10 and 20 uM) inhibits H-Ras (V12)-induced AP-1 activation in HEK293 cells. Ras stimulation of Raf-1 activity is significantly decreased by MCP110 (20 μM) [1].MCP110 (1, 2, 5, 10, and 20 μM) shows a dose-dependent inhibition of elevated Raf-1 activity in fibrosarcoma HT1080 cells[1].MCP110 (20 μM) decreases cyclin D level stimulated by the treatment with EGF (100 ng/mL), platelet-derived growth factor (20 ng/mL) , serum, or phorbol 12-myristate 13-acetate (100 nM) in A549 cells[1].


[1]. Juran Kato-Stankiewicz,et al. Inhibitors of Ras/Raf-1 Interaction Identified by Two-Hybrid Screening Revert Ras-dependent Transformation Phenotypes in Human Cancer Cells. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14398-403.