GSK717是一种有效的、选择性的NOD2(核苷酸结合寡聚结构域2)抑制剂。GSK717抑制壁酰二肽(MDP)诱导的NOD2介导的信号转导，抑制MDP刺激的HEK293/hNOD2细胞分泌IL-8中的IC50为400nM。
货号:ajcx30742
CAS:1595278-21-9
分子式:C28H28N4O2
分子量：452.55
溶解度:DMSO: 250 mg/mL (552.43 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1].

GSK717 blocks synergy between NOD2 and TLR2. GSK717 does not affect NOD1, TNFR1 and TLR2-mediated responses. GSK717 (5 μM) inhibits the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP[1].

[1]. Rickard DJ, et al. Identification of benzimidazole diamides as selective inhibitors of the nucleotide-binding oligomerization domain 2 (NOD2) signaling pathway. PLoS One. 2013;8(8):e69619. Published 2013 Aug 1.