Ezetimibephenoxyglucuronide(Ezetimibeglucuronide)是Ezetimibe的活性代谢物，具有抗高脂蛋白血症效果。Ezetimibe是有效的胆固醇吸收抑制剂。
货号:ajcx30632
CAS:190448-57-8
分子式:C30H29F2NO9
分子量：585.55
溶解度:N/A
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity[1]. Ezetimibe is a potent cholesterol absorption inhibitor[2].

After oral administration, Ezetimibe is absorbed in the small intestine and more than 80% of Ezetimibe metabolized to Ezetimibe Glucuronide[1].

[1]. Stolk MF, et al. Severe hepatic side effects of ezetimibe. Clin Gastroenterol Hepatol. 2006 Jul;4(7):908-11. [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532.