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(E/Z)-E64FC26
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(E/Z)-E64FC26图片
规格:98%
分子量:340.38
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
(E/Z)-E64FC26是E-E64FC26和Z-E64FC26的混合物。E64FC26(E-E64FC26)是蛋白质二硫键异构酶(PDI)家族的一种有效的泛抑制剂,对PDIA1、PDIA3、PDIA4、TXNDC5和PDIA6的IC50分别为1.9、20.9、25.9、16.3和25.4μM。E64FC26显示抗骨髓瘤活性。
货号:ajcx29810
CAS:2285446-67-3
分子式:C19H23F3O2
分子量:340.38
溶解度:DMSO: 100 mg/mL (293.79 mM)
纯度:98%
存储:Store at -20°C
库存:现货

Background:

(E/Z)-E64FC26 is a mixture complex of E-E64FC26 and Z-E64FC26. E64FC26 (E-E64FC26) is a potent pan-inhibitor of the protein disulfide isomerase (PDI) family, with IC50s of 1.9, 20.9, 25.9, 16.3, and 25.4 μM against PDIA1, PDIA3, PDIA4, TXNDC5, and PDIA6. E64FC26 shows anti-myeloma activity[1][2].


[1]. Nathan G. Dolloff, et al. Indene derivatives and uses thereof. US20190062298A1. [2]. Robinson RM, et al. Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma. Leukemia. 2019 Apr;33(4):1011-1022.