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Perphenazine Sulfoxide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Perphenazine Sulfoxide图片
规格:98%
分子量:420
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An active metabolite of perphenazine
货号:ajcx28528
CAS:10078-25-8
分子式:C21H26ClN3O2S
分子量:420
溶解度:DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: 3 mg/ml,PBS (pH 7.2): insol
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Perphenazine sulfoxide is an active metabolite of the typical antipsychotic perphenazine .1It is formedviaoxidation of perphenazine. Perphenazine sulfoxide selectively binds to dopamine D2and α1-adrenergic receptors (α1-ARs) over α2-ARs (Kis= 5.9, 24, and 683 nM, respectively) in rat brain.2It increases thrombin-induced increases in phosphatidylinositol levels in isolated human platelets when used at a concentration of 5 µM.3

1.Hals, P.A., Hall, H., and Dahl, S.G.Phenothiazine drug metabolites: Dopamine D2 receptor, α1- and α2-adrenoceptor bindingEur. J. Pharmacol.125(3)373-381(1986) 2.Tharmapathy, P., Fukami, M.H., and Holmsen, H.The stimulatory effects of cationic amphiphilic drugs on human platelets treated with thrombinBiochem. Pharmacol.60(9)1267-1277(2000)