规格: | 98% |
分子量: | 420 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Background:
Perphenazine sulfoxide is an active metabolite of the typical antipsychotic perphenazine .1It is formedviaoxidation of perphenazine. Perphenazine sulfoxide selectively binds to dopamine D2and α1-adrenergic receptors (α1-ARs) over α2-ARs (Kis= 5.9, 24, and 683 nM, respectively) in rat brain.2It increases thrombin-induced increases in phosphatidylinositol levels in isolated human platelets when used at a concentration of 5 µM.3
1.Hals, P.A., Hall, H., and Dahl, S.G.Phenothiazine drug metabolites: Dopamine D2 receptor, α1- and α2-adrenoceptor bindingEur. J. Pharmacol.125(3)373-381(1986) 2.Tharmapathy, P., Fukami, M.H., and Holmsen, H.The stimulatory effects of cationic amphiphilic drugs on human platelets treated with thrombinBiochem. Pharmacol.60(9)1267-1277(2000)