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Montbretin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Montbretin A图片
规格:98%
分子量:1229.1
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An acylated flavonol glycoside with antidiabetic activity
货号:ajcx28252
CAS:115712-92-0
分子式:C53H64O33
分子量:1229.1
溶解度:DMF: 1 mg/ml,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): 2 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Montbretin A is an acylated flavonol glycoside that has been found inC. crocosmiifloraand has antidiabetic activity.1,2,3It inhibits human pancreatic α-amylase andB. fibrisolvensamylase B (Kis = 8.1 and 1,600 nM, respectively).2Montbretin A reduces blood glucose levels in Zucker diabetic fatty rats when administered at a dose of 7.4 mg/kg per day.4

1.Asada, Y., Hirayama, Y., and Furuya, T.Acylated flavonols from Crocosmia crocosmiifloraPhytochemistry27(5)1497-1501(1988) 2.Williams, L.K., Zhang, X., Caner, S., et al.The amylase inhibitor montbretin A reveals a new glycosidase inhibition motifNat. Chem. Biol.11(9)691-696(2015) 3.Irmisch, S., Jo, S., Roach, C.R., et al.Discovery of UDP-glycosyltransferases and BAHD-acyltransferases involved in the biosynthesis of the antidiabetic plant metabolite montbretin APlant Cell30(8)1864-1886(2018) 4.Yuen, V.G., Coleman, J., Withers, S.G., et al.Glucose lowering effect of montbretin A in Zucker diabetic fatty ratsMol. Cell Biochem.411(1-2)373-381(2016)