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3,3&rsquo-Sulfinyldipropanoic Acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3,3&rsquo-Sulfinyldipropanoic Acid图片
规格:98%
分子量:194.2
包装与价格:
包装价格(元)
100mg电议
500mg电议
1g电议

产品介绍
An APE1/Ref-1 inhibitor
货号:ajcx28220
CAS:3680-08-8
分子式:C6H10O5S
分子量:194.2
溶解度:DMF: 3 mg/ml,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): 3 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

3,3’-Sulfinyldipropanoic acid is an inhibitor of apurinic-apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1; IC50= 40 µM), an enzyme involved in base excision repair.1It is also a building block in the synthesis of the protein cross-linking probe disuccinimidyl sulfoxide .2

1.Zawahir, Z., Dayam, R., Deng, J., et al.Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitorsJ. Med. Chem.52(1)20-32(2009) 2.Kao, A., Chiu, C.-l., Vellucci, D., et al.Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexesMol. Cell. Proteomics10(1)M110.002212(2011)