规格: | 98% |
分子量: | 194.2 |
包装 | 价格(元) |
100mg | 电议 |
500mg | 电议 |
1g | 电议 |
Background:
3,3’-Sulfinyldipropanoic acid is an inhibitor of apurinic-apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1; IC50= 40 µM), an enzyme involved in base excision repair.1It is also a building block in the synthesis of the protein cross-linking probe disuccinimidyl sulfoxide .2
1.Zawahir, Z., Dayam, R., Deng, J., et al.Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitorsJ. Med. Chem.52(1)20-32(2009) 2.Kao, A., Chiu, C.-l., Vellucci, D., et al.Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexesMol. Cell. Proteomics10(1)M110.002212(2011)