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IA-Alkyne
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
IA-Alkyne图片
包装:5mg
规格:98%
市场价:846元
分子量:265.09

产品介绍
IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) 是一种 TRP 通道 (TRPC) 激动剂,具有研究呼吸道感染的潜力。
货号:ajcx27956
CAS:930800-38-7
分子式:C8H12INO
分子量:265.09
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Broad spectrum cysteine reactive probe. Covalently binds cysteine residues in proteins. Can be utilized for covalent fragment-based ligand discovery (FBLD) and to identify Zn2+-binding cysteines. Used as a click-chemistry handle to attach a fluorophore or biotin to reactive cysteines in proteins for visualization by in-gel fluorescence or identification by mass spectrometry, respectively. Covalently binds cysteine residues in and activates TRPA1 channels.


Backus et al (2016) Proteome-wide covalent ligand discovery in native biological systems. Nature 534 570 PMID:27309814 |Pace and Weerapana et al (2014) A competitive chemical-proteomic platform to identify zinc-binding cysteines. ACS Chem.Biol. 9 258 PMID:24111988 |Macpherson et al (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445 541 PMID:17237762