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LNT 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LNT 1图片
包装:5mg
规格:98%
市场价:2867元
分子量:332.33

产品介绍
Potent flap endonuclease 1 (FEN1) inhibitor; induces DNA damage response
货号:ajcx27644
CAS:824983-91-7
分子式:C15H12N2O5S
分子量:332.33
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent flap endonuclease 1 (FEN1) inhibitor (IC50 = 46.4 nM for hFEN1-336Δ). Cytotoxic to SW620 colorectal cancer cells in vitro; induces DNA damage response.


Exell et al (2016) Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site. Nat.Chem.Bio. 12 815 PMID:27526030 |Ward et al (2017) Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes. PLoS One 12 e0179278 PMID:28628639