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SPT Imidazopyridine 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SPT Imidazopyridine 1图片
规格:98%
分子量:364.44
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Potent serine palmitoyl transferase inhibitor
货号:ajcx27356
CAS:1933533-18-6
分子式:C22H24N2O3
分子量:364.44
溶解度:<36.44mg/ml in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.


Genin et al (2016) Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 59 5904 PMID:27213958