Potent serine palmitoyl transferase inhibitor
货号:ajcx27356
CAS:1933533-18-6
分子式:C22H24N2O3
分子量：364.44
溶解度:<36.44mg/ml in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent serine palmitoyl transferase (SPT) inhibitor (IC50 = 5 nM). Dose-dependently inhibits incorporation of 14C-serine into ceramide. Reduces plasma ceramide levels in vivo. Also increases plasma HDL and reduces vLDL cholesterol levels in rats.

Genin et al (2016) Imidazopyridine and pyrazolopiperidine derivatives as novel inhibitors of serine palmitoyl transferase. J.Med.Chem. 59 5904 PMID:27213958