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M 084 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
M 084 hydrochloride图片
规格:98%
分子量:225.72
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
TRPC4/5 channel blocker; antidepressant and anxiolytic
货号:ajcx27242
CAS:N/A
分子式:C11H15N3.HCl
分子量:225.72
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

TRPC4/5 channel blocker (IC50 values are 3.7-10.3 and 8.2 μM, respectively). Also weakly blocks TRPC3 channels. Exhibits rapid antidepressant and anxiolytic effects in vivo.


Zhu et al (2015) Identification and optimization of 2-aminobenzimidazole derivatives as novel inhibitors of TRPC4 and TRPC5 channels. Br.J.Pharmacol. 172 3495 PMID:25816897 |Yang et al (2015) Acute treatment with a novel TRPC4/C5 channel inhibitor produces antidepressant and anxiolytic-like effects in mice. PLoS One 10 e0136255 PMID:26317356