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AMG 853
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AMG 853图片
包装:10mg
规格:98%
市场价:2272元
分子量:609.49

产品介绍
Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist
货号:ajcx27190
CAS:1169483-24-2
分子式:C28H27Cl2FN2O6S
分子量:609.49
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent prostaglandin D2 (PGD2, CRTH2) receptor antagonist (IC50 values are 8 and 35 nM, respectively in plasma). Inhibits PGD2-induced down modulation of CRTH2 on CD16- granulocytes in human whole blood as well as PGD2-induced cAMP response in platelets. Inhibits PGD2-induced airway constriction in vivo. Orally bioavailable.


Liu et al (2011) Discovery of AMG 853, a CRTH2 and DP dual antagonist. ACS Med.Chem.Lett. 2 326 PMID:24900313