Potent MCT1 inhibitor
货号:ajcx27044
CAS:227321-12-2
分子式:C25H29N3O2S
分子量：435.58
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent MCT1 inhibitor (IC50 = 0.5 nM); blocks proliferation of Raji lymphoma cells in vitro. Also inhibits lactate uptake in breast cancer cells in vitro.

Murray et al (2005) Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat.Chem.Biol. 1 371 PMID:16370372 |Wang et al (2014) Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J.Med.Chem. 57 7317 PMID:25068893