An internal standard for the quantification of carbinoxamine
货号:ajcx25366
CAS:N/A
分子式:C16H13ClD6N2O·C4H4O4
分子量：412.9
溶解度:Acetonitrile: soluble,DMSO: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Carbinoxamine-d₆is intended for use as an internal standard for the quantification of carbinoxamine by GC- or LC-MS. Carbinoxamine is a competitive histamine H₁receptor antagonist (K_i= 2.3 nM) and first generation antihistamine.¹It is also an L-type calcium channel inhibitor (K_i= 1.08 nM).²Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC₅₀s = 250 and 480 nM, respectively). Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis.

1.Tran, V.T., Chang, R.S.L., and Snyder, S.H.Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramineProc. Natl. Acad. Sci. U.S.A.75(12)6290-6294(1978) 2.Carosati, E., Budriesi, R., Ioan, P., et al.Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screeningJ. Med. Chem.51(18)5552-5565(2008)