KRP 297 是一种 PPARα 和 PPARγ 激动剂，可能用于治疗 2 型糖尿病和血脂异常。
货号:ajcx24208
CAS:213252-19-8
分子式:C20H17F3N2O4S
分子量：438.4
溶解度:DMSO: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

KRP 927 is a thiazolidinedione dual agonist of PPARα and PPARγ (EC₅₀s = 149 and 83 nM, respectively, in transactivation assays).¹It decreases hyperglycemia and hyperinsulinemia inob/obmice in a dose-dependent manner. KRP 927 (10 or 30 mg/kg) reduces serum total cholesterol and triglyceride levels in hamsters.

1.Doebber, T.W., Kelly, L.J., Zhou, G., et al.MK-0767, a novel dual PPARα/γ agonist, displays robust antihyperglycemic and hypolipidemic activitiesBiochem. Biophys. Res. Commun.318(2)323-328(2004)