您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > CAY10771
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
CAY10771
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAY10771图片
规格:98%
分子量:559.9
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A dual agonist of FXR and PPARδ
货号:ajcx24020
CAS:2522599-79-5
分子式:C28H25Cl3N2O4
分子量:559.9
溶解度:Acetonitrile: 5 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 µM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 µM.


1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Chem.63(15)8369-8379(2020)