An internal standard for the quantification of vardenafil
货号:ajcx23716
CAS:1189685-70-8
分子式:C23H27D5N6O4S
分子量：493.6
溶解度:Water: 0.11 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Vardenafil-d₅is intended for use as an internal standard for the quantification of vardenafil by GC- or LC-MS. Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC₅₀s = 0.2-1.2 nM) and PDE6 (IC₅₀= 2 nM).^1,2,3It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC₅₀s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment.⁴Chronic vardenafil administration at a dose of 2 mg/kg for five weeks to subordinate mice reduces the latency to mount and increases the frequency of mounting behavior.⁵Formulations containing vardenafil have been used in the treatment of erectile dysfunction.

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