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Vapendavir-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vapendavir-d5图片
规格:98%
分子量:387.5
包装与价格:
包装价格(元)
500ug电议
1mg电议
5mg电议

产品介绍
Vapendavir-d5 是氘标记的 Vapendavir。
货号:ajcx23714
CAS:N/A
分子式:C21H21D5N4O3
分子量:387.5
溶解度:DMSO: Soluble,Methanol: Soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Vapendavir-d5is intended for use as an internal standard for the quantification of vapendavir by GC- or LC-MS. Vapendavir is a capsid-binding antiviral agent.1,2It binds to a pocket in the human rhinovirus (HRV) strain HRV2 VP1 capsid protein and inhibits the cytopathic effects of HRV2 and HRV14 in HeLa Ohio cells (EC50s = 1 and 5 ng/ml, respectively), as well as in a panel of 39 HRV clinical isolates (median EC50= 7.3 ng/ml).1Vapendavir inhibits replication in a panel of 21 enterovirus 71 (EV71) isolates with an average EC50value of 0.7 μM.2


1.Feil, S.C., Hamilton, S., Krippner, G.Y., et al.An orally available 3-ethoxybenzisoxazole capsid binder with clinical activity against human rhinovirusACS Med. Chem. Lett.3(4)303-307(2012) 2.Tijsma, A., Franco, D., Tucker, S., et al.The capsid binder vapendavir and the novel protease inhibitor SG85 inhibit enterovirus 71 replicationAntimicrob. Agents Chemother.58(11)6990-6992(2014)