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Suprafenacine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Suprafenacine图片
规格:98%
分子量:282.3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
An inhibitor of tubulin polymerization with anticancer activity
货号:ajcx23544
CAS:1477482-50-0
分子式:C16H18N4O
分子量:282.3
溶解度:DMSO: 10 mg/ml
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Suprafenacine is an inhibitor of tubulin polymerization (IC50= 0.38 μM) with anticancer activity.1It inhibits the proliferation of HeLa, Jurkat, SNU-16, MDA-MB-231, A549, SH-SY5Y, HCT15, and KB-3-1 cells (IC50s = 83-381.2 nM) and P-glycoprotein-enriched KB-VI cells (IC50= 215.7 nM). Suprafenacine (10 μM) increases phosphorylation of JNK and Bcl-2 and induces apoptosis and cell cycle arrest at the G2/M phase in HeLa cells. Suprafenacine (20 mg/kg) reduces tumor growth in an HCT15 colon adenocarcinoma mouse xenograft model.


1.Choi, B.-H., Chattopadhaya, S., Thanh, L.N., et al.Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilizationPLoS One9(10)e110955(2014)