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Sodium 4-Phenylbutyrate-d11
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sodium 4-Phenylbutyrate-d11图片
规格:98%
分子量:197.3
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
An internal standard for the quantification of sodium 4-phenylbutyrate
货号:ajcx23484
CAS:1392208-11-5
分子式:C10D11O2.Na
分子量:197.3
溶解度:DMSO: 25 mM,Water: 100 mM
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Sodium 4-Phenylbutyrate-d11is intended for use as an internal standard for the quantification of sodium 4-phenylbutyrate by GC- or LC-MS. Sodium 4-phenylbutyrate is a chemical chaperone that has been shown to rescue the trafficking of misfolded proteins.1,2It also weakly blocks histone deacetylase activity (IC50= 0.4 mM), which results in cell cycle arrest, differentiation, and/or apoptosis of various tumors.3,4Formulations containing sodium 4-phenylbutyrate have been used for the treatment of urea cycle disorders.


1.Stewart, G.A., Ridscale, R., Martin, E.P., et al.4-Phenylbutyric acid treatment rescues trafficking and processing of a mutant surfactant protein-CAmerican Journal of Respiration, Cell, and Molecular Biology47(3)324-331(2012) 2.Bradbury, N.A.Focus on "sodium 4-phenylbutyrate downregulates Hsc70: Implications for intracellular trafficking of δF508-CFTR"Am. J. Physiol. Cell Physiol.278(2)C257-C258(2000) 3.Lu, Q., Wang, D.S., Chen, C.S., et al.Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitorsJ. Med. Chem.48(17)5530-5535(2005) 4.Ammerpohl, O., Trauzold, A., Schniewind, B., et al.Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cellsBr. J. Cancer96(1)73-81(2007)