Internal standard for the quantification of latanoprost (free acid)
货号:ajcx22784
CAS:1224443-47-3
分子式:C23H30D4O5
分子量：394.5
溶解度:DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 100 mg/ml,PBS (pH 7.2): .5 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Latanoprost (free acid)-d₄(Lat-FA-d₄) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC-or LC-mass spectrometry. Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.¹It is the isopropyl ester of a PGF_2αanalog containing an aromatic group (17-phenyl) in the ω-chain. As an isopropyl ester, latanoprost acts as a prodrug which is converted to Lat-FA by endogenous esterase enzymes. Lat-FA is a potent FP receptor agonist with an EC₅₀value of 3.6 nM for human FP receptors, which is twice the potency of PGF_2αand more than 200 times more potent latanoprost.²The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid.³However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.⁴

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