| 规格: | 98% |
| 分子量: | 1188.4 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
Background:
Kallidin (380-389) is a short-lived kinin peptide involved in inflammation and pain.1It binds to bradykinin B2(IC50= 0.63 nM) and B1receptors (Ki= 3.23 nM) and acts as an agonist.1,2,3It is formed in tissue, including the brain,viacleavage of low molecular weight kininogen (LMWK) by kallikrein serine proteases released in response to injury or inflammation and can be converted into bradykinin.1Kallidin levels in interstitial muscle are increased in women with work-related trapezius myalgia.4
1.Dray, A.Kinins and their receptors in hyperalgesiaCan. J. Physiol. Pharmacol.75(6)704-712(1997) 2.Bastian, S., Loillier, B., Paquet, J.L., et al.Stable expression of human kinin B1 receptor in 293 cells: Pharmacological and functional characterizationBr. J. Pharmacol.122(2)393-399(1997) 3.Hess, J.F., Borkowski, J.A., Macneil, T., et al.Differential pharmacology of cloned human and mouse B2 bradykinin receptorsMol. Pharmacol.45(1)1-8(1994) 4.Gerdle, B., Hilgenfeldt, U., Larsson, B., et al.Bradykinin and kallidin levels in the trapezius muscle in patients with work-related trapezius myalgia, in patients with whiplash associated pain, and in healthy controls - a microdialysis study of womenPain139(3)578-587(2008)
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