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Dacarbazine-d6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dacarbazine-d6图片
包装:1mg
规格:98%
市场价:3985元
分子量:188.2

产品介绍
Dacarbazine-d6 (Imidazole Carboxamide-d6) 是氘标记的 Dacarbazine。 Dacarbazine (DTIC-Dome; DTIC) 是一种抗肿瘤剂。它对黑色素瘤具有显着的活性。
货号:ajcx22192
CAS:1185241-28-4
分子式:C6H4D6N6O
分子量:188.2
溶解度:DMSO: slightly, heated,Methanol: slightly, heated
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Dacarbazine-d6is intended for use as an internal standard for the quantification of dacarbazine by GC- or LC-MS. Dacarbazine is a DNA alkylating prodrug that is activated by P450 enzymes in liver microsomes.1Following activation, it is converted, through a series of reactions, into a methyldiazonium cation that alkylates DNA at all phases of the cell cycle and induces apoptosis.In vitro, dacarbazine inhibits the growth of B16/F1, A-875, and SK-MEL-5 melanoma and non-cancerous WI-38 lung fibroblast and L-02 hepatocyte cell lines (IC50s = 260, 287, 380, 526, and 367 μM, respectively).2Dacarbazine toxicity to 518A2 and SK-MEL-28 melanoma cell lines increases in a time-dependent manner with IC50values of 121 and >400 μM, respectively, following a 1 hour incubation and 2.5 and 50 μM, respectively, following a 96 hour incubation.3In vivo, dacarbazine (70 mg/kg, once every 2 days) decreases tumor volume by 59.1% in a B16/F1 murine melanoma model in mice.2Formulations containing dacarbazine have been used in the treatment of metastatic melanoma and for Hodgkin's lymphoma in combination with other antineoplastic agents.


1.Marchesi, F., Turriziani, M., Tortorelli, G., et al.Triazene compounds: Mechanism of action and related DNA repair systemsPharmacol. Res.56(4)275-287(2007) 2.Jin, J.-l., Gong, J., Yin, T.-j., et al.PTD4-apoptin protein and dacarbazine show a synergistic antitumor effect on B16-F1 melanoma in vitro and in vivoEur. J. Pharmacol.654(1)17-25(2011) 3.Valiahdi, S.M., Heffeter, P., Jakupec, M.A., et al.The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell linesMelanoma Res.19(5)283-293(2009)