A neuropeptide with diverse biological activities
货号:ajcx22154
CAS:N/A
分子式:C34H55D5N3O6.Cl
分子量：647.4
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CV-6209-d₅contains five deuterium atoms at the 1, 1, 2, 2, and 2 positions of the ethyl pyridinium moiety. It is intended for use as an internal standard for the quantification of CV-6209 by GC- or LC-mass spectrometry. CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor, inhibiting aggregation of rabbit and human platelets induced by PAF with IC₅₀values of 75 and 170 nM, respectively.¹It has little action on platelet aggregation induced by arachidonic acid, ADP, or collagen.¹CV-6209 is bioavailable, as it prevents PAF-induced hypotension in rats, while not blocking hypotension triggered by arachidonic acid , histamine, bradykinin , or isoproterenol .¹CV-6209 is used to study the role of PAF receptor signalingin vitroandin vivo.^2,3

1.Terashita, Z., Imura, Y., Takatani, M., et al.CV-6209, a highly potent antagonist of platelet activating factor in vitro and in vivoJournal of Pharmacology and Experimental Therapeutics242263-268(1987) 2.Leong, H.S., Mahesh, B.M., Day, J.R., et al.Vimentin autoantibodies induce platelet activation and formation of platelet-leukocyte conjugates via platelet-activating factorJournal of Leukocyte Biology83(2)263-271(2008) 3.Musio, S., Pedotti, P., Mantegazza, R., et al.Anaphylaxis to a self-peptide in the absence of mast cells or histamineLaboratory Investigation89(4)398-405(2009)