A PAD3 inhibitor
货号:ajcx22014
CAS:1671088-84-8
分子式:C21H22Cl2N4O2
分子量：433.3
溶解度:DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

CAY10727 is an inhibitor of protein arginine deiminase 3 (PAD3; k_inact/K_I= 15,600 M^-1min^-1).¹It is selective for PAD3 over PAD1, -2, and -4 (k_inact/K_Is = 360, 1,110, and 1,460 M^-1min^-1, respectively).

1.Jamali, H., Khan, H.A., Stringer, J.R., et al.Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment methodJ. Am. Chem. Soc.137(10)3616-3621(2015)